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Treatment of mice with low doses of the protonophore 2, 4-dinitrophenol promotes enhanced tissue respiratory rates, improved serological glucose, triglyceride and insulin levels, decrease of reactive oxygen species levels and tissue DNA and protein oxidation, as well as reduced body weight. Importantly, 2, 4-dinitrophenol-treated animals also presented enhanced longevity. Our results demonstrate that mild mitochondrial uncoupling is a highly effective in vivo antioxidant strategy, and describe the first therapeutic intervention capable of effectively reproducing the physiological, metabolic and lifespan effects of caloric restriction in healthy mammals. (2) The Mitochondrial Uncoupling Agent 2, 4-Dinitrophenol Improves Mitochondrial Function, Attenuates Oxidative Damage, and Increases White Matter Sparing in the Contused Spinal Cord. J Neurotrauma. 2004 Oct;21(10):1396-404 Abstract The purpose of this study was to investigate the potential neuroprotective efficacy of the mitochondrial uncoupler 2, 4-dinitrophenol (DNP) in rats following a mild to moderate spinal cord contusion injury.
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Any attempt to prevent overeating, excessive weight gain and obesity, as well as any weight loss diet must be accompanied by details of not only what we eat, but also on the correct way to consume our food. Mastering the art of mindful eating will help you enjoy more and lose more! A Research Based Article by Calorie Secrets Experts Author Info Holly Klamer, RD Holly is a registered dietitian (RDN) with a MS degree in nutrition and exercise science. She teaches culinary nutrition classes at Kalamazoo Valley Community College. You can connect with Holly on LinkedIn. Trustworthy Health Information Calorie Secrets is certified by Health On the Net Foundation for trustworthy health information, verify here. All articles are based on research evidence and are written by Certified Nutritionist and Fitness Experts.
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I cut out sugar, bad fats and unfriendly carbs, and replaced them with healthy choices, " she explains. "I turn 50 this year, and have a second chance for a glorious life with new beginnings. " (Image: Supplied) Catching up with Natalie at her local gym, she's adamant there will be no commenting about the impending birth of a second son to her ex-husband and his 34-year-old former staffer, saying only "he's a man I no longer know. " She happily admits that the four daughters – Bridgette, 22, Julia, 20, Caroline, 19, and Odette, 16 – she shares with Barnaby became her secret weapon in getting to where she is today, and remain her biggest supporters. Mum-of-four Natalie says her daughters are her biggest supporters. (Image: Supplied) "They thought I'd gone mad when I told them I would be strutting my stuff wearing nothing more than a skimpy bikini, flexing my muscles for all to see! " laughs Natalie, who looks years younger than her former self. "But they're very proud of me – watching as I rediscovered my confidence and enjoying how empowered I've become – and I do like my girls thinking their mum has a smoking hot body! "
